Quinolines and derivatives
Medchemexpress LLC 17beta-methoxy-3-propoxyestra-1,3,5(10)-triene | 39219-28-8 | MFCD00867247 | 99.9% | 328.49 | C22H32O2 | 200 MG
Promestriene is a synthetic diethyl-ether derivative of estradiol that acts as a locally effective estrogen. It is used in research to model topical estrogenic activity and has reported efficacy against vaginal atrophy while showing minimal systemic absorption. Provided as a high-purity research reagent for in vitro and analytical applications; not for human use.
- Locally active estrogenic agent.
- Used to study vaginal atrophy and estrogen receptor activity.
- Low systemic absorption when applied topically.
- Chemical formula C22H32O2; molecular weight 328.49.
- High purity (≈99.9%) as supplied.
- For research use only; not for clinical use.
Medchemexpress LLC PH-797804 | 586379-66-0 | 98.9% | 477.30 g·mol⁻¹ | C22H19BrF2N2O3 | 200 MG
PH-797804 is an ATP-competitive, selective inhibitor of p38 mitogen-activated protein kinases (p38α/p38β) used in research to probe p38-mediated signaling and inflammatory responses. It shows nanomolar biochemical potency and demonstrable cellular activity that reduces LPS-induced cytokine production.
- Selective ATP-competitive p38α/p38β inhibitor.
- Nanomolar biochemical potency (p38α IC50 26 nM; Ki 5.8 nM).
- Demonstrated cellular activity reducing LPS-induced TNF-α and IL-1β release.
- Does not inhibit JNK2, supporting target selectivity.
- High supplied purity and solid white to off-white appearance.
- Suitable for biochemical and cellular assay applications.
Medchemexpress LLC TLR7/8 agonist 1 dihydrochloride | 1620278-72-9 | MFCD31657341 | 99.7% | 432.39 | C22H27Cl2N5 | 10 MG
TLR7/8 agonist 1 dihydrochloride is a small-molecule imidazoquinoline research compound that acts as a dual agonist of Toll-like receptors 7 and 8. It is intended for use in immunology and inflammation studies and demonstrates low-nanomolar activity in receptor assays, suitable for both in vitro and in vivo experimental applications.
- Dual agonist of TLR7 and TLR8 with low-nanomolar potency.
- High reported purity (99.7%).
- Molecular weight 432.39 and formula C22H27Cl2N5.
- High solubility in DMSO (83.33 mg/mL) and compatible with common in vivo vehicles.
- Supplied as an off-white to light yellow solid and available as a DMSO solution.
- Storage: 4°C sealed; in solvent store at -80°C for long term.
Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.9% | 500.8 g/mol | C21H17ClF4N4O4 | 50 MG
Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor used as a research reagent and analytical standard. It exhibits potent inhibition of VEGFR, PDGFR, KIT, RET, and RAF kinases and is used in preclinical assays to study antitumor and antiangiogenic activity.
- High purity (≈99.9%) suitable for analytical work.
- Monohydrate form with molecular weight 500.8 g/mol.
- Useful as an analytical standard and research reagent in kinase assays.
- Available in small, quantified laboratory packages for preclinical studies.
![Medchemexpress LLC (2R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butamid | 145337-55-9 | 99.4% | 315.41 g/mol | C15H29N3O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245623.png-250.jpg)
Medchemexpress LLC (2R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butamid | 145337-55-9 | 99.4% | 315.41 g/mol | C15H29N3O4 | 100 MG
Ro 31-9790 is a synthetic matrix metalloproteinase (MMP) inhibitor provided for research use. It serves as a biochemical probe to study MMP-related activity in vitro and in cell-based assays. The compound is identified by CAS 145337-55-9 and is characterized by a defined molecular formula and high reported purity.
- Acts as a matrix metalloproteinase inhibitor for research applications.
- High purity, approximately 99.4%.
- Molecular weight 315.41 g/mol; formula C15H29N3O4.
- Suitable as a research-grade chemical for biochemical and cell biology studies.
- Synonyms and systematic names are available in chemical databases for cross-referencing.
![Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000246635.png-250.jpg)
Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG
CJ033466 is a research-grade selective 5-HT4 receptor partial agonist with a reported EC50 of 9 nM and demonstrated gastroprokinetic activity. It is supplied as a purified solid intended for in vitro and in vivo pharmacology research.
- Selective 5-HT4 receptor partial agonist (EC50 9 nM).
- Reported gastroprokinetic activity in preclinical studies.
- High purity (98.29%), suitable for pharmacology research.
- Molecular formula C19H28ClN5O; molecular weight 377.91 g/mol.
- Soluble in DMSO (50 mg/mL) with ultrasonic/warming up to 80°C.
- Storage: solid at 4°C; in solvent -80°C (6 months), -20°C (1 month).
- Available in research quantities including 200 mg.
Medchemexpress LLC Snx-2112 | 908112-43-6 | 99.5% | 464.48 g/mol | C23H27F3N4O3 | 200 MG
SNX-2112 is an Hsp90 inhibitor research compound used to study Hsp90-mediated signaling and cancer cell biology. It binds Hsp90 isoforms with low-nanomolar affinity and induces degradation of client proteins, making it suitable for biochemical and cellular assays.
- High purity (99.5%) appropriate for sensitive assays.
- Molecular weight 464.48 g/mol.
- White to off-white solid, easy to weigh and dissolve.
- Stable when stored as a powder at -20°C for long-term storage.
- Supplied in a 200 MG quantity for laboratory use.
Medchemexpress LLC Nilotinib monohydrochloride monohydrate | 923288-90-8 | MFCD18251359 | >98.0% | 583.99 g/mol | C28H25ClF3N7O2 | 200 MG
Nilotinib monohydrochloride monohydrate is the monohydrochloride monohydrate salt of nilotinib, a second-generation Bcr-Abl tyrosine kinase inhibitor used in research to study Bcr-Abl-driven signaling and oncology applications. Provided as a high-purity research compound, it is suitable for biochemical and cellular assays investigating kinase inhibition and resistance mutations.
- High purity suitable for research applications.
- Soluble in DMSO; limited solubility in water.
- Active against Bcr-Abl and many resistance-associated mutants.
- Molecular weight 583.99 g/mol for formulation and dosing calculations.
- Supplied as a stable solid salt for ease of handling and storage.
Medchemexpress LLC N6-(2-phenylethyl)adenosine | 20125-39-7 | MFCD00055128 | 99.4% | 371.39 g/mol | C18H21N5O4 | 200 MG
N6-(2-Phenylethyl)adenosine is an adenosine derivative provided as a research-grade small molecule for studies of adenosine receptor pharmacology. It is supplied as a white to off-white solid with high reported purity and is intended for laboratory research use.
- CAS number 20125-39-7.
- Molecular formula C18H21N5O4.
- Molecular weight 371.39 g/mol.
- Purity 99.4%.
- Physical form white to off-white solid.
- Pack size 200 mg.
- Storage powder: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC (S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one | 654059-21-9 | 99.8% | 266.34 g/mol | C14H22N2O3 | 100 MG
BAY 59-9435 (HSL-IN-2) is a potent, selective small-molecule inhibitor of hormone-sensitive lipase (HSL) with an IC50 of 0.023 μM. It exhibits cellular activity (28 nM in 3T3-L1 cells for inhibition of forskolin-stimulated lipolysis) and is supplied as a high-purity solid for research use, with recommended storage conditions to maintain stability.
- Potent and selective HSL inhibition (IC50 0.023 μM).
- Demonstrated cellular activity in adipocyte assays (28 nM).
- High purity suitable for biochemical and cellular studies.
- Stable as powder under recommended storage conditions.
- Soluble in DMSO for assay preparation.
Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.7% | 500.8 g/mol | C21H17ClF4N4O4 | 1 ML
Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor used in research. The item is provided as a 10 mM solution in a 1 mL vial for laboratory and analytical applications; it is intended for research use only.
- High purity suitable for research (purity 99.7%).
- Monohydrate form for consistent chemical properties.
- Concentrated solution (10 mM) enabling small-volume dosing.
- Convenient 1 mL vial for storage and handling.
- Useful as a kinase inhibitor in in vitro studies.
Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | MFCD09970504 | 99.9% | 564.65 | C29H32N4O6S | 5 MG
Ruboxistaurin mesylate is an orally active, ATP-competitive, and selective protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal/eye disorders, and cardiovascular disease. It is supplied as a solid with high reported purity and is soluble in DMSO for in vitro applications.
- Selective PKCβ inhibitor with low-nanomolar potency.
- Orally active small molecule suitable for in vitro and in vivo studies.
- High reported purity (~99.9%) for research applications.
- Solid form, orange to red color, easy handling and storage.
- Soluble in DMSO at 50 MG/ML (88.55 mM); ultrasonic assistance may be required.
- Storage guidance: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Stiripentol | 49763-96-4 | MFCD00869310 | >=98.0% | 234.29 g/mol | C14H18O3 | 200 MG
Stiripentol is an anticonvulsant research compound used as adjunct therapy in seizure disorders such as Dravet syndrome. This product listing represents a 200 mg research reagent with analytical identifiers and purity information available from supplier and reference databases.
- High purity ≥98.0% (HPLC).
- Molecular formula C14H18O3.
- Molecular weight 234.29 g/mol.
- Pack contains 200 mg of compound.
- For research use only.